Yerba mate has long been known as a weight loss drink, and data suggest its benefits go far beyond that. Its leaves contains caffeine, theobromine, and theophylline, which work together to provide a milder, more pleasant lift than coffee or other popular stimulating beverages. While caffeine is the main stimulant in yerba mate, theobromine and theophylline are mild stimulants that also contribute to its energizing effects. "Theobromine is a chemical precursor to caffeine. While it doesn’t directly affect the central nervous system, it can increase heart rate, act as a diuretic, and help relax the airways," Le said. Moreover, the decrease in glucagon was more noticeable in people with high cholesterol. "While yerba mate may help lower blood sugar and HbA1c levels in people with Type 2 diabetes, it seems to work best when combined with healthy eating habits," Jena Brown, a registered dietitian and owner of Victorem Performance Nutrition, wrote in an email to The Epoch Times. Of note, glycated hemoglobin (HbA1c) is a longer-term marker of blood glucose levels. "Its antioxidant properties might also support people with prediabetes. However, we still need more evidence to be sure," Brown stated. "Yerba mate may support weight loss and help maintain healthy cholesterol and blood sugar levels, all of which play a role in promoting better heart health," Brown said. Results showed that yerba mate extract could reduce cancer cell growth by inducing cell death (apoptosis). In animal experiments, it also helped reduce the growth of tumors and blood vessel formation (angiogenesis) without affecting body weight. Oxidative stress occurs when there is an excess of free radicals or harmful molecules in the body and not enough antioxidants to neutralize them. This imbalance can damage cells and increase the risk of health problems.